Aaron is an Endowed Professor and Chair of Human Genetics with a history of innovation in computational genomics. His laboratory develops and applies software and new algorithms to study the origins, patterns, and consequences of mutations in diverse contexts including rare diseases, infertility, and cancer. Their tools are used daily by thousands of researchers worldwide. They innovate by devising genomic, algorithmic, and data science techniques to advance precision medicine. They have created over 50 widely-used, open-source software tools that advance genomic discovery worldwide.